abstract：:Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in b...

journal_title：Antiviral research

authors： Zhu HY,Han L,Shi XL,Wang BL,Huang H,Wang X,Chen DF,Ju DW,Feng MQ

更新日期：2015-01-01 00:00:00

abstract：:There are no drugs approved specifically to treat disseminated adenovirus (Ad) infections in humans. Cidofovir is active against Ad in cell culture, and it is used frequently in the clinic with disseminated infection in pediatric transplant patients; however, controlled clinical studies have not been conducted to prov...

journal_title：Antiviral research

authors： Tollefson AE,Spencer JF,Ying B,Buller RM,Wold WS,Toth K

更新日期：2014-12-01 00:00:00

abstract：:The 27th International Conference on Antiviral Research (ICAR) was held in Raleigh, North Carolina, USA from May 12 to 16, 2014. This article summarizes the principal invited lectures. John Drach (Elion Award) described the early days of antiviral drugs and their novel modes of action. Piet Herdewijn (Holý Award) used...

journal_title：Antiviral research

authors： Vere Hodge RA

更新日期：2014-11-01 00:00:00

abstract：:Dextran sulfate (DS) is a negatively charged sulfated polysaccharide that suppresses the replication of influenza A viruses. The suppression was thought to be associated with inhibition of the hemagglutinin-dependent fusion activity. However, we previously showed that suppression by DS was observed not only at the ini...

journal_title：Antiviral research

authors： Yamada H,Nagao C,Haredy AM,Mori Y,Mizuguchi K,Yamanishi K,Okamoto S

更新日期：2014-11-01 00:00:00

abstract：:Influenza viruses, which can cross species barriers and adapt to new hosts, pose a constant potential threat to human health. The influenza pandemic of 2009 highlighted the rapidity with which an influenza virus can spread worldwide. Currently available antivirals have a number of limitations against influenza, and no...

journal_title：Antiviral research

authors： Ilyushina NA,Donnelly RP

更新日期：2014-11-01 00:00:00

abstract：:Flavivirus methyltransferase is a genetically-validated antiviral target. Crystal structures of almost all available flavivirus methyltransferases contain S-adenosyl-L-methionine (SAM), the methyl donor molecule that co-purifies with the enzymes. This raises a possibility that SAM is an integral structural component r...

journal_title：Antiviral research

authors： Noble CG,Li SH,Dong H,Chew SH,Shi PY

更新日期：2014-11-01 00:00:00

abstract：:Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for ca...

journal_title：Antiviral research

authors： Tuppurainen ES,Pearson CR,Bachanek-Bankowska K,Knowles NJ,Amareen S,Frost L,Henstock MR,Lamien CE,Diallo A,Mertens PP

更新日期：2014-09-01 00:00:00

abstract：:Although in vitro studies have been performed to dissect the mechanism of action of IFNα, detailed in vivo studies on the long-term effects of IFNα on monocytes have not been performed. Here we examined peripheral blood from 14 chronic HCV patients at baseline and 12 weeks after start of IFNα-based therapy. Monocytes ...

journal_title：Antiviral research

authors： Hou J,Groothuismink ZM,Koning L,Roomer R,van IJcken WF,Kreefft K,Liu BS,Janssen HL,de Knegt RJ,Boonstra A

更新日期：2014-09-01 00:00:00

abstract：:Commercial vaccines against human papillomavirus (HPV) have low uptake due to parental autonomy, dosing regimen, cost, and cold chain storage requirements. Carrageenan (CG)-based formulations prevent HPV infection in vitro and in vivo but data are needed on the durability of anti-HPV activity and the effect of seminal...

journal_title：Antiviral research

authors： Rodríguez A,Kleinbeck K,Mizenina O,Kizima L,Levendosky K,Jean-Pierre N,Villegas G,Ford BE,Cooney ML,Teleshova N,Robbiani M,Herold BC,Zydowsky T,Fernández Romero JA

更新日期：2014-08-01 00:00:00

abstract：:The family Flaviviridae comprises several major human pathogens including hepatitis C virus (genus hepacivirus), yellow fever virus, West Nile virus and dengue virus (genus flavivirus). Flaviviridae genomes comprise a single-stranded RNA segment encoding a single polyprotein that is subsequently processed into 10 matu...

journal_title：Antiviral research

authors： Caillet-Saguy C,Lim SP,Shi PY,Lescar J,Bressanelli S

更新日期：2014-05-01 00:00:00

abstract：:Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that are widely used for the treatment of hypercholesterolemia. Besides their cholesterol-lowering effect, statins have been reported to have antiviral activity against a variety of viruses, including hepatitis C virus (HCV). Several stat...

journal_title：Antiviral research

authors： Verpaalen B,Neyts J,Delang L

更新日期：2014-05-01 00:00:00

abstract：:Coxsackievirus A16 (CA16) is one of the main causative agents of hand, foot and mouth disease (HFMD), which is a common infectious disease in children. CA16 infection may lead to severe nervous system damage and even death in humans. However, study of the pathogenesis of CA16 infection and development of vaccines and ...

journal_title：Antiviral research

authors： Liu Q,Shi J,Huang X,Liu F,Cai Y,Lan K,Huang Z

更新日期：2014-05-01 00:00:00

abstract：:RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrades viral and cellul...

journal_title：Antiviral research

authors： Park IH,Kwon YC,Ryu WS,Ahn BY

更新日期：2014-04-01 00:00:00

abstract：:Classical swine fever virus (CSFV) is the causative pathogen of classical swine fever (CSF), a highly contagious disease of swine. Mx proteins are interferon-induced dynamin-like GTPases present in all vertebrates with a wide range of antiviral activities. Although Zhao et al. (2011) have reported that human MxA can i...

journal_title：Antiviral research

authors： He DN,Zhang XM,Liu K,Pang R,Zhao J,Zhou B,Chen PY

更新日期：2014-04-01 00:00:00

abstract：:Enterovirus-71 (EV71) is one of the major causative reagents for hand-foot-and-mouth disease. In particular, EV71 causes severe central nervous system infections and leads to numerous dead cases. Although several inactivated whole-virus vaccines have entered in clinical trials, no antiviral agent has been provided for...

journal_title：Antiviral research

authors： Wang Y,Qing J,Sun Y,Rao Z

更新日期：2014-03-01 00:00:00

abstract：:Interleukin (IL)28-B polymorphism has been related to interferon response in the treatment of hepatitis C, but its role in chronic hepatitis B (CHB) therapy is still poorly understood. We aimed to investigate the effect of IL28-B polymorphisms in the treatment with pegylated-interferon (PEG-IFN) of patients with CHB. ...

journal_title：Antiviral research

authors： Boglione L,Cusato J,Allegra S,Esposito I,Patti F,Cariti G,Di Perri G,D'Avolio A

更新日期：2014-02-01 00:00:00

abstract：:The single tablet regimen of the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) tenofovir disoproxil fumarate (TDF), emtricitabine (FTC), and the non-nucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) is approved for the treatment of HIV-1 infection in treatment-naïve adults. Previous...

journal_title：Antiviral research

authors： Kulkarni R,Feng JY,Miller MD,White KL

更新日期：2014-01-01 00:00:00

abstract：:End stage liver disease caused by chronic infection with the hepatitis C virus (HCV) is a leading indication for liver transplantation, yet outcomes are poor since the liver graft is rapidly re-infected by HCV. Antibodies against the essential HCV receptor CD81 have been shown to inhibit HCV cell entry in vitro and in...

journal_title：Antiviral research

authors： Deest M,Westhaus S,Steinmann E,Manns MP,von Hahn T,Ciesek S

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:This paper presents the public health rationale for multipurpose prevention technologies (MPTs) for sexual and reproductive health (SRH) based on regional trends in demographic and SRH indicators. It then distils important lessons gleaned from the introduction of contraceptive and reproductive health product...

journal_title：Antiviral research

authors： Brady M,Manning J

更新日期：2013-12-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：:The 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT)-like compounds with homocyclic moieties at the N-1 of the pyrimidinedione, including the highly potent lead compound IQP-0410, inhibit HIV-1 at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism involving allosteric inhibition at...

journal_title：Antiviral research

authors： Buckheit RW Jr,Watson Buckheit K,Sturdevant CB,Buckheit RW 3rd

更新日期：2013-11-01 00:00:00

abstract：:Fifty-nine US isolates of HSV-1 and HSV-2 obtained between 1998 and 2004 were tested for sensitivity to the helicase-primase inhibitor, pritelivir (AIC316, BAY 57-1293) by plaque-reduction assay. All isolates, which were collected prior to any clinical use of primase-helicase inhibitors, were sensitive and showed mean...

journal_title：Antiviral research

authors： Field HJ,Huang ML,Lay EM,Mickleburgh I,Zimmermann H,Birkmann A

更新日期：2013-11-01 00:00:00

abstract：:Lamivudine is no longer recommended as first-line therapy for chronic hepatitis B. The same advice has been made for adefovir and telbivudine, due to their relatively weak anti-viral activity and low resistance barrier, respectively. Instead, either tenofovir or entecavir is the currently preferred anti-HBV agent, giv...

journal_title：Antiviral research

authors： Soriano V,McMahon B

更新日期：2013-11-01 00:00:00

abstract：:Many aspects of the biology and epidemiology of influenza B viruses are far less studied than for influenza A viruses, and one of these aspects is efficacy and resistance to the clinically available antiviral drugs, the neuraminidase (NA) inhibitors (NAIs). Acute respiratory infections are one of the leading causes of...

journal_title：Antiviral research

authors： Burnham AJ,Baranovich T,Govorkova EA

更新日期：2013-11-01 00:00:00

abstract：:Therapeutic strategies controlling human cytomegalovirus (hCMV) infection are limited due to adverse side effects and emergence of antiviral resistance variants. A compound being evaluated for treating hCMV disease is maribavir (MBV) which disrupts replication by inhibiting the viral kinase pUL97. Previous studies hav...

journal_title：Antiviral research

authors： Reitsma JM,Terhune SS

更新日期：2013-11-01 00:00:00

abstract：:The outbreak of severe acute respiratory syndrome (SARS) in 2003 was the first emergence of an important human pathogen in the 21st century. Responding to the epidemic provided clinicians with extensive experience in diagnosing and treating a novel respiratory viral disease. In this article, we review the experience o...

journal_title：Antiviral research

authors： Cheng VC,Chan JF,To KK,Yuen KY

更新日期：2013-11-01 00:00:00

abstract：:Laninamivir, a potent neuraminidase (NA) inhibitor, is an active metabolite of laninamivir octanoate (code name: CS-8958) which is a long acting NA inhibitor and is commercially available under the brand name Inavir in Japan to complete the treatment of influenza by a single inhalation. It is supposed that the long ac...

journal_title：Antiviral research

authors： Kakuta M,Kubo S,Tanaka M,Tobiume S,Tomozawa T,Yamashita M

更新日期：2013-10-01 00:00:00

abstract：:Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in ...

journal_title：Antiviral research

authors： Dapat C,Kondo H,Dapat IC,Baranovich T,Suzuki Y,Shobugawa Y,Saito K,Saito R,Suzuki H

更新日期：2013-09-01 00:00:00

abstract：:Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because mos...

journal_title：Antiviral research

authors： Chang J,Block TM,Guo JT

更新日期：2013-09-01 00:00:00

abstract：:Infection by one of the 4 distinct serotypes of dengue virus (DENV) threatens >40% of the world's population, with no efficacious vaccine or antiviral agent currently available. DENV replication through the virus-encoded nonstructural protein (NS) 5 protein occurs in the infected cell cytoplasm, but NS5 from DENV2 has...

journal_title：Antiviral research

authors： Tay MY,Fraser JE,Chan WK,Moreland NJ,Rathore AP,Wang C,Vasudevan SG,Jans DA

更新日期：2013-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, invariably fatal neurologic disorder resulting from upper and lower motor neuron degeneration, which typically develops during the sixth or seventh decade of life, and is diagnosed based on standard clinical criteria. Its underlying cause remains undetermined. The ...

journal_title：Antiviral research

authors： Alfahad T,Nath A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Lactoferrin (LF) is a glycoprotein present in human milk with known antimicrobial effects. In vitro, LF has demonstrated antiviral activity against respiratory syncytial virus (RSV). We sought to assess the effect of bovine (b)LF in RSV replication, lung inflammation and function, cytokine profiles and clini...

journal_title：Antiviral research

authors： Gualdi L,Mertz S,Gomez AM,Ramilo O,Wittke A,Mejias A

更新日期：2013-08-01 00:00:00

abstract：:Human cytomegalovirus infection can lead to life-threatening clinical manifestations particularly in the immunocompromised host. Current therapy options face severe limitations leading to a continued search for alternative drug candidates. Viral replication is dependent on a balanced interaction between viral and cell...

journal_title：Antiviral research

authors： Hutterer C,Wandinger SK,Wagner S,Müller R,Stamminger T,Zeitträger I,Godl K,Baumgartner R,Strobl S,Marschall M

更新日期：2013-08-01 00:00:00

abstract：:DAS181 is an inhaled bacterial sialidase which functions by removing sialic acid (Sia) from the surface of epithelial cells, preventing attachment and subsequent infection by respiratory viruses that utilize Sia as a receptor. DAS181 is typical of bacterial sialidases in cleaving Sia α2-3 and Sia α2-6 linkages, and it...

journal_title：Antiviral research

authors： Nicholls JM,Moss RB,Haslam SM

更新日期：2013-06-01 00:00:00

abstract：:Although canine rabies has been eliminated from industrialized countries, infected dogs remain the primary source of human and livestock exposures in Asia, Africa and much of South America. Human deaths are the most important direct economic impact of canine rabies, followed by livestock losses and the cost of PEP, wh...

journal_title：Antiviral research

authors： Shwiff S,Hampson K,Anderson A

更新日期：2013-05-01 00:00:00

abstract：:The dengue fever virus (DENV) and the yellow fever virus (YFV) are members of the genus flavivirus in the family Flaviviridae. An estimated 50-100 million cases of DENV infections occur each year and approximately half a million patients require hospitalization. There is no vaccine or effective antiviral treatment ava...

journal_title：Antiviral research

authors： De Burghgraeve T,Selisko B,Kaptein S,Chatelain G,Leyssen P,Debing Y,Jacobs M,Van Aerschot A,Canard B,Neyts J

更新日期：2013-05-01 00:00:00

abstract：:Lack of vaccines and efficient control measures complicate the control and eradication of African swine fever (ASF). Limitations of conventional inactivated and attenuated virus-based vaccines against African swine fever virus (ASFV) highlight the need to use new technologies to develop efficient and safe vaccines aga...

journal_title：Antiviral research

authors： Argilaguet JM,Pérez-Martín E,López S,Goethe M,Escribano JM,Giesow K,Keil GM,Rodríguez F

更新日期：2013-04-01 00:00:00

abstract：:The introduction of potent combination therapies in the mid-90s had a tremendous effect on AIDS mortality. However, drug resistance has been a major factor contributing to antiretroviral therapy failure. Currently, there are 26 drugs approved for treating human immunodeficiency virus (HIV) infections, although some of...

journal_title：Antiviral research

authors： Menéndez-Arias L

更新日期：2013-04-01 00:00:00

abstract：:Rotavirus (RV) and norovirus (NoV) are the two most important causes of viral gastroenteritis. While vaccine remains an effective prophylactic strategy, development of other approaches, such as passive immunization to control and treat clinical infection and illness of these two pathogens, is necessary. Previously we ...

journal_title：Antiviral research

authors： Dai YC,Zhang XF,Tan M,Huang P,Lei W,Fang H,Zhong W,Jiang X

更新日期：2013-03-01 00:00:00

abstract：:In Western countries, chronic hepatitis C virus (HCV)-infection mostly affects former and active substance users. The effect of active substance use on interferon (IFN)-responsiveness and therapy efficacy is not well understood. In this study, we compared natural killer (NK) cell activity and function in healthy contr...

journal_title：Antiviral research

authors： Hotho DM,Kreefft K,Groothuismink ZM,Janssen HL,de Knegt RJ,Boonstra A

更新日期：2013-03-01 00:00:00